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KMID : 1098420040120020113
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Korean Journal of Medicinal Crop Science
2004 Volume.12 No. 2 p.113 ~ p.117
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Effect of Medicinal Plant Extracts on Alcohol Metabolism in Rat Liver
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Lee Seung-Eun
Bang Jin-Ki
Ahn Tae-Jin
Yu Young-Ju
Chung Hae-Gon
Kim Geum-Suk
Seong Nak-Sul
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Abstract
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The experiment was conducted to evaluate the effects of medicinal plants on ethanol-metabolism. Sprague Dawley rats divided into 6 groups (n=8), fed with 10% ethanol and diets supplemented with each 1% of four plant extracts, {alpha}-tocopherol (as positive control) and fiber (as negative control) for 4 weeks. Group supplemented with plant extract of Ulmus davidiana showed the most high value (322 nM NADH/min/mg protein) in alcohol dehydrogenase (ADH) activity among the experimented groups (144{sim}312;nM;NADH/min/mg;protein) at p<0.05. Groups fed with Lagerstroemia indica and Zelkova serrata extract-supplemented diets indicated high activity in aldehyde dehydrogenase (ALDH, 16.7 & 12.3 M NADH/min/mg protein), which were comparatively lower than 20.1 M NADH/min/mg protein of {alpha}-tocopherol fed group. All of the groups fed with plant extracts indicated very low GPT activities (13.9{sim}17.3;IU/l) compared to those (146.1 & 128.6 IU/l) fed with {alpha}-tocopherol and fiber at p<0.05. From these results, it is suggested that Lagerstroemia indica have a potent ethanol-metabolizing activity.
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KEYWORD
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alcohol dehydrogenase, aldehyde dehydrogenase, microsomal ethanol-oxidizing system, glutamate-pyruvate transferase, medicinal plant
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